BDBM50513074 CHEMBL4467526

SMILES Nc1ncc(C#N)c(n1)N1CC[C@H]1c1nn2ccc(Cl)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=UOPPKPSZIRYWNN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50513074   

LigandPNGBDBM50513074(CHEMBL4467526)
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50513074(CHEMBL4467526)
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in antihuman IgM-stimulated AKT phosphorylation at Ser473 residue preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50513074(CHEMBL4467526)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human full-length His-tagged PI3K p110gamma expressed in baculovirus expression system using PIP2 as substrate measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed