BDBM50513063 CHEMBL4445566
SMILES Clc1ccn2nc([C@@H]3CCN3c3ncnc4[nH]cc(C#N)c34)n(-c3ccccc3)c(=O)c12
InChI Key InChIKey=LNFWSNQWRMMEBJ-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50513063
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Hutchison Medipharma
Curated by ChEMBL
Hutchison Medipharma
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in antihuman IgM-stimulated AKT phosphorylation at Ser473 residue preincubated for...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Hutchison Medipharma
Curated by ChEMBL
Hutchison Medipharma
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant human full-length His-tagged PI3K p110gamma expressed in baculovirus expression system using PIP2 as substrate measured aft...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Hutchison Medipharma
Curated by ChEMBL
Hutchison Medipharma
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Hutchison Medipharma
Curated by ChEMBL
Hutchison Medipharma
Curated by ChEMBL
Affinity DataIC50: 945nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110beta/untagged recombinant full length human p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair