BDBM50513004 CHEMBL4521353
SMILES CC(C)(C)C(=O)N1N=CC[C@H]1c1ccccc1
InChI Key InChIKey=NJQVSLWJBLPTMD-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50513004
Affinity DataIC50: 16nMAssay Description:Inhibition of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)-16...More data for this Ligand-Target Pair
Affinity DataIC50: 631nMAssay Description:Inhibition of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)-16...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human GST/His-tagged RIP1 (1 to 375 residues) expressed in baculovirus expression system assessed as reduction in autophosphorylation m...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necroptosis measured after 24 hrs by cell titer-glo luminesc...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of GST-tagged RIPK1 (1 to 375) (unknown origin) by fluorescent polarization based binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of GST-tagged RIPK1 (1 to 375) (unknown origin) incubated for 4 hrs by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of GST tagged RIP1 (1 to 375 residues) (unknown origin) incubated for 4 hrs in presence of ATP by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of GST-tagged RipK1 (1-375) residues (unknown origin) by FP-based binding assayMore data for this Ligand-Target Pair