BDBM50512922 CHEMBL4533700

SMILES O=C(Nc1cnn2cccnc12)[C@@H]1CCCC[C@H]1C(=O)c1ccc(cc1)-c1cc[nH]n1

InChI Key InChIKey=MJJOCVSZEMTHJQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50512922   

LigandPNGBDBM50512922(CHEMBL4533700)
Affinity DataIC50: 40nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction in calcium ionophore-stimulated LTB4 production preincubated for 30 mins followed by ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50512922(CHEMBL4533700)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP450 assessed as maximum reduction in metabolite formation using coumarin based substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50512922(CHEMBL4533700)
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of human ERG by high-throughput electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50512922(CHEMBL4533700)
Affinity DataIC50: 32nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed