BDBM50512880 CHEMBL4468379

SMILES C[C@H](Nc1ncnc2[nH]cnc12)C1=Nc2cccc(Cl)c2S(=O)(=O)N1c1ccccc1

InChI Key InChIKey=XIKOUZAURDUGPE-UHFFFAOYSA-N

Data  6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50512880   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Zhejiang University

Curated by ChEMBL

LigandBDBM50512880(CHEMBL4468379)Copy SMILESCopy InChI

Affinity DataIC50: 3.64E+3nMAssay Description:Inhibition of His-tagged recombinant human full length PI3K p110alpha/p85alpha expressed in baculovirus expression system using lipid substrate incub...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoKEGGPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Zhejiang University

Curated by ChEMBL

LigandBDBM50512880(CHEMBL4468379)Copy SMILESCopy InChI

Affinity DataIC50: 156nMAssay Description:Inhibition of His-tagged recombinant human full length PI3K p110gamma expressed in baculovirus expression system using lipid substrate incubated for ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoKEGGPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Zhejiang University

Curated by ChEMBL

LigandBDBM50512880(CHEMBL4468379)Copy SMILESCopy InChI

Affinity DataIC50: 4.60nMAssay Description:Inhibition of His-tagged recombinant human PI3K p110delta/p85alpha using lipid substrate incubated for 2 hrs by ADP-Glo assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoKEGGPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Zhejiang University

Curated by ChEMBL

LigandBDBM50512880(CHEMBL4468379)Copy SMILESCopy InChI

Affinity DataIC50: 766nMAssay Description:Inhibition of His6-tagged recombinant full length human N-terminal PI3Kbeta expressed in baculovirus infected Sf21 cells using lipid substrate incuba...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoKEGGPC cidPC sidSimilars

In Depth
Date in BDB:
2/23/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50512880(CHEMBL4468379)Copy SMILESCopy InChI

Affinity DataIC50: 0.100nMAssay Description:Inhibition of PI3Kdelta in human SUDHL6 cellsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoKEGGPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Zhejiang University

Curated by ChEMBL

LigandBDBM50512880(CHEMBL4468379)Copy SMILESCopy InChI

Affinity DataIC50: 34nMAssay Description:Inhibition of PI3Kgamma in human SUDHL6 cellsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoKEGGPC cidPC sidSimilars

In Depth
Date in BDB:
2/20/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL