BDBM50512333 CHEMBL4443805

SMILES CNc1cncc(n1)-c1c[nH]c2nc(Nc3ccc(cc3)N3CCOCC3)nc(OC3CCN(CC3)C(=O)C=C)c12

InChI Key InChIKey=SCHZJSMNFSXTPZ-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50512333   

TargetTyrosine-protein kinase ITK/TSK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50512333(CHEMBL4443805)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged ITK (352 to 617 residues) expressed in baculovirus infected Sf21 insect cells using STK substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50512333(CHEMBL4443805)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR kinase domain (696 to end residues) expressed in baculovirus infected Sf21 insect cells us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50512333(CHEMBL4443805)
Affinity DataIC50: 74nMAssay Description:Inhibition of recombinant full length human C-terminal His-tagged LCK cytoplasmic domain expressed in baculovirus expression system using fluorophore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50512333(CHEMBL4443805)
Affinity DataIC50: 198nMAssay Description:Inhibition of recombinant full-length human His-tagged BLK cytoplasmic domain expressed in baculovirus expression system using fluorophore-labeled ty...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50512333(CHEMBL4443805)
Affinity DataIC50: 54nMAssay Description:Inhibition of tracer 222 binding to recombinant full-length human His-tagged MAP3K7/MAP3K7IP1 (437 to 504 residues) expressed in baculovirus expressi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50512333(CHEMBL4443805)
Affinity DataIC50: 996nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged BTK expressed in baculovirus infected Sf21 insect cells using STK substrate by HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50512333(CHEMBL4443805)
Affinity DataIC50: 123nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged JAK3 (781 to end residues) expressed in baculovirus infected Sf21 cells using STK as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50512333(CHEMBL4443805)
Affinity DataKi:  6.30nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged ITK (352 to 617 residues) expressed in baculovirus infected Sf21 insect cells using STK substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed