BDBM50512278 CHEMBL4475724

SMILES OC(=O)C(Cc1c[nH]c2ccccc12)N1C(=S)S\C(=C/c2ccc3cc(OCc4ccc(Br)cc4)ccc3c2)C1=O

InChI Key InChIKey=NZUUNLGIKOLXCV-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50512278   

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50512278(CHEMBL4475724)
Affinity DataIC50: 360nMAssay Description:Inhibition of human recombinant GST-tagged PTP1B expressed in Escherichia coli BL21 (DE3) using pNPP as substrate measured for 2 mins by colorimetric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50512278(CHEMBL4475724)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP2 (catalytic domain 1116 to 2162 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50512278(CHEMBL4475724)
Affinity DataIC50: 2.91E+4nMAssay Description:Inhibition of human recombinant GST-tagged LAR (catalytic domain 1275 to 1613 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50512278(CHEMBL4475724)
Affinity DataIC50: 1.11E+3nMAssay Description:Inhibition of human recombinant GST-tagged SHP1 (catalytic domain 244 to 570 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetM-phase inducer phosphatase 2(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50512278(CHEMBL4475724)
Affinity DataIC50: 320nMAssay Description:Inhibition of human recombinant GST-tagged CDC25B expressed in Escherichia coli BL21 (DE3) using pNPP as substrate measured for 2 mins by colorimetri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50512278(CHEMBL4475724)
Affinity DataIC50: 780nMAssay Description:Inhibition of human recombinant GST-tagged TCPTP (catalytic domain 41 to 1075 residues) expressed in Escherichia coli BL21 (DE3) using pNPP as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Yanbian University College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50512278(CHEMBL4475724)
Affinity DataKi:  70nMAssay Description:Competitive inhibition of human recombinant GST-tagged PTP1B expressed in Escherichia coli BL21 (DE3) using pNPP as substrate assessed as inhibitor c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed