BDBM50511697 CHEMBL4475854

SMILES C[C@H]1C[C@H](CCN1C(=O)CC(C(F)(F)F)C(F)(F)F)Oc1c(C)c(NC(=O)c2ccc(C)nc2)cn2ncnc12

InChI Key InChIKey=FUKNWBDJYWPXRK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50511697   

TargetNuclear receptor ROR-gamma(Human)
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50511697(CHEMBL4475854)
Affinity DataIC50: 130nMAssay Description:Inhibition of RORgammat in human whole blood assessed as reduction in anti-CD3/anti-CD28 monoclonal antibodies/IL-18/IL-23-stimulated IL-17A producti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50511697(CHEMBL4475854)
Affinity DataIC50: 51nMAssay Description:Inverse agonist activity at recombinant human GAL4-fused RORgammat LBD (247 to 497 residues) transfected in HEK293T cells assessed as inhibition of R...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed