BDBM50511298 CHEMBL4451058

SMILES CC(C)CNC(=O)n1c2ccc(cc2oc1=O)C1CCN(C)CC1

InChI Key InChIKey=AYXQGWOLRJUITD-UHFFFAOYSA-N

Data  3 IC50  1 EC50  1 Koff

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50511298   

TargetN-acylethanolamine-hydrolyzing acid amidase(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50511298(CHEMBL4451058)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human NAAA expressed in HEK293 cells using PAMCA as fluorogenic substrate preincubated for 30 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50511298(CHEMBL4451058)
Affinity DataEC50:  410nMAssay Description:Inhibition of acid ceramidase in Krabbe's disease patient-derived primary fibroblasts using Rbm14-12 as substrate measured after 2 hrs by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50511298(CHEMBL4451058)
Affinity DataIC50: 166nMAssay Description:Inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate preincubated for 10 mins followed by substrate addition and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcid ceramidase(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50511298(CHEMBL4451058)
Affinity DataKon:  0.00250M-1s-1Assay Description:Time-dependent inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50511298(CHEMBL4451058)
Affinity DataIC50: 70nMAssay Description:Inhibition of human FAAH expressed in HEK293 cells using AMC arachidonyl amide as fluorogenic substrate preincubated for 50 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed