BDBM50510947 CHEMBL4453871

SMILES COc1ncc(cc1NS(=O)(=O)c1ccccc1C(F)(F)F)-c1ccc(s1)-c1cnc2C(=O)N(C)Cc2c1

InChI Key InChIKey=DJMFZWCDWOMIOE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50510947   

TargetPerforin-1(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50510947(CHEMBL4453871)
Affinity DataIC50: 780nMAssay Description:Inhibition of perforin (unknown origin) assessed as reduction in perforin-mediated cell lysis in human Jurkat T cells incubated for 30 mins by 51Cr r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetPerforin-1(Human)
University of Auckland

Curated by ChEMBL
LigandPNGBDBM50510947(CHEMBL4453871)
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of perforin in human KHYG-1 cells pre-treated with compound for 20 mins assessed as reduction in KHYG-1 cells-mediated cell lysis of human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed