BDBM50510886 CHEMBL4516586

SMILES COc1cc2ncnc(Nc3ccc(NC(=O)C=C)cc3)c2cc1OCCN1CCOCC1

InChI Key InChIKey=VHCZHJHCTYDXLJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50510886   

TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50510886(CHEMBL4516586)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human recombinant GST-tagged EGFR L858R/T790M mutant (catalytic domain 695 to end) expressed in baculovirus-infected Sf9 cells assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50510886(CHEMBL4516586)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50510886(CHEMBL4516586)
Affinity DataIC50: 105nMAssay Description:Inhibition of human recombinant GST-tagged EGFR (catalytic domain 695 to end) expressed in baculovirus-infected Sf9 cells assessed as reduction in ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Arromax Pharmatech

Curated by ChEMBL
LigandPNGBDBM50510886(CHEMBL4516586)
Affinity DataIC50: 105nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed