BDBM50510780 CHEMBL4464845

SMILES [H][C@@]12CC[C@@](C)(C(N)=N[C@]1(C)c1cc(NC(=O)c3ncc(Cl)cc3C)ccc1F)S2(=O)=O

InChI Key InChIKey=OCEVYHBEVRPQEN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50510780   

TargetBeta-secretase 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50510780(CHEMBL4464845)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1 (unknown origin) assessed as reduction in amyloidbeta 40 level after 24 hrs by cell-based sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCathepsin D(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50510780(CHEMBL4464845)
Affinity DataIC50: 1.74E+6nMAssay Description:Inhibition of recombinant Cathepsin D (unknown origin) expressed in CHO cells preincubated for 1 hr followed by substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50510780(CHEMBL4464845)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1 (unknown origin) preincubated for 1 hr followed by substrate addition and measured after 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed