BDBM50510524 CHEMBL4525220

SMILES F[C@@H]1CCN(C1)c1ccc2c(C(=O)NCC3CCCC(F)(F)C3)c(Cl)ccc2n1

InChI Key InChIKey=JWYYLBNLUIBSIN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50510524   

TargetP2X purinoceptor 7(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM50510524(CHEMBL4525220)
Affinity DataIC50: 4.90nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced YO PRO dye uptake preincubated for 20 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM50510524(CHEMBL4525220)
Affinity DataIC50: 118nMAssay Description:Antagonist activity at P2X7R in LPS-stimulated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preincubated for 30 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM50510524(CHEMBL4525220)
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at mouse P2X7 receptor assessed as inhibition of BzATP-induced YO PRO dye uptake preincubated for 20 mins followed by YO PRO dye ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed