BDBM50510513 CHEMBL4531148

SMILES C[C@H]1CCC[C@@](O)(CNC(=O)c2c(Cl)ccc3nc(ccc23)N2CC[C@@H](F)C2)C1

InChI Key InChIKey=TYVVUDSQBIAFBI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50510513   

TargetP2X purinoceptor 7(Rat)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM50510513(CHEMBL4531148)
Affinity DataIC50: 640nMAssay Description:Antagonist activity at rat P2X7 receptor assessed as inhibition of BzATP-induced YO PRO dye uptake preincubated for 20 mins followed by YO PRO dye an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM50510513(CHEMBL4531148)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at P2X7R in LPS-stimulated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preincubated for 30 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM50510513(CHEMBL4531148)
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity at mouse P2X7 receptor assessed as inhibition of BzATP-induced YO PRO dye uptake preincubated for 20 mins followed by YO PRO dye ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM50510513(CHEMBL4531148)
Affinity DataIC50: 4.5nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced YO PRO dye uptake preincubated for 20 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed