BDBM50510263 CHEMBL4449906

SMILES Cc1cnc(Nc2cc(F)c(N3CCOCC3)c(F)c2)nc1-c1cc2CN(CCc2o1)C(=O)CC#N

InChI Key InChIKey=LJACZUSJYLWSLY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50510263   

TargetTyrosine-protein kinase JAK2(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50510263(CHEMBL4449906)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of JAK2 (unknown origin) using TK-substrate-biotin as substrate preincubated for 5 mins followed by substrate addition and measured by 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50510263(CHEMBL4449906)
Affinity DataIC50: 88nMAssay Description:Inhibition of JAK3 (unknown origin) using TK-substrate-biotin as substrate preincubated for 5 mins followed by substrate addition and measured by 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50510263(CHEMBL4449906)
Affinity DataIC50: 586nMAssay Description:Inhibition of JAK2 in human TF-1 cells assessed as reduction in GM-CSF-induced cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50510263(CHEMBL4449906)
Affinity DataIC50: 623nMAssay Description:Inhibition of JAK3 in human HT-2 cells assessed as reduction in IL-2-induced cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50510263(CHEMBL4449906)
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of JAK2 V617F mutant in human HEL cells assessed as reduction in cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed