BDBM50510232 CHEMBL4586472

SMILES CC(C)n1cc(C(=O)Nc2cc3cn[nH]c3cc2F)c2ncc(cc12)-c1ccc(N)cc1

InChI Key InChIKey=NWKPQWAZOMCVOH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50510232   

TargetAcetyl-CoA carboxylase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50510232(CHEMBL4586472)
Affinity DataIC50: 150nMAssay Description:Inhibition of ACC1 in human HCT116 cells assessed as reduction in [14C]acetate uptake preincubated for 60 mins followed by [14C]acetate addition and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50510232(CHEMBL4586472)
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant human ACC1 expressed in Sf9 cells using acetyl Co-A as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetyl-CoA carboxylase 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50510232(CHEMBL4586472)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant human ACC2 expressed in Sf9 cells using acetyl Co-A as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed