BDBM50509971 CHEMBL4457168::US11608332, Example 87

SMILES CO[C@@H]1CCN(Cc2cc3CCCN(C(=O)Nc4cc(N[C@@H]5CCOC5)c(cn4)C#N)c3nc2C=O)C1=O

InChI Key InChIKey=SZIHMIDPPNPYHZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50509971   

TargetFibroblast growth factor receptor 4(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50509971(CHEMBL4457168 | US11608332, Example 87)
Affinity DataIC50: 1nMAssay Description:Inhibition of FGFR4 (unknown origin) incubated for 60 mins by caliper microfluidic mobility shift technology based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50509971(CHEMBL4457168 | US11608332, Example 87)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) incubated for 60 mins by caliper microfluidic mobility shift technology based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50509971(CHEMBL4457168 | US11608332, Example 87)
Affinity DataIC50: 1.10nMAssay Description:In this experiment, the inhibitory effect of the compounds on FGFR4 kinase activity was tested by a fluorescence resonance energy transfer (TR-FRET) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50509971(CHEMBL4457168 | US11608332, Example 87)
Affinity DataIC50: 1.00E+4nMAssay Description:In this experiment, the inhibitory effect of the compounds on FGFR1 kinase activity was tested by a fluorescence resonance energy transfer (TR-FRET) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent