BDBM50509954 CHEMBL4446965::US11608332, Example 46

SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN4CC[C@H](OC)C4=O)c(C=O)nc23)ncc1C#N

InChI Key InChIKey=LTUJTWUNXSABMP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50509954   

TargetFibroblast growth factor receptor 1(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50509954(CHEMBL4446965 | US11608332, Example 46)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) incubated for 60 mins by caliper microfluidic mobility shift technology based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50509954(CHEMBL4446965 | US11608332, Example 46)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of FGFR4 (unknown origin) incubated for 60 mins by caliper microfluidic mobility shift technology based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50509954(CHEMBL4446965 | US11608332, Example 46)
Affinity DataIC50: 0.920nMAssay Description:In this experiment, the inhibitory effect of the compounds on FGFR4 kinase activity was tested by a fluorescence resonance energy transfer (TR-FRET) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Southeast University

Curated by ChEMBL
LigandPNGBDBM50509954(CHEMBL4446965 | US11608332, Example 46)
Affinity DataIC50: 1.00E+4nMAssay Description:In this experiment, the inhibitory effect of the compounds on FGFR1 kinase activity was tested by a fluorescence resonance energy transfer (TR-FRET) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2023
Entry Details
Go to US Patent