BDBM50509461 CHEMBL4440832

SMILES Oc1ccc2cc(Oc3ccccc3C(=O)Nc3nc4cc(O)c(O)cc4s3)ccc2c1

InChI Key InChIKey=FRSGRURBNYCMBJ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50509461   

TargetGenome polyprotein(DENV-2)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50509461(CHEMBL4440832)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of Dengue virus NS2B/NS3 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50509461(CHEMBL4440832)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of N-terminal hexa-histidine tagged Zika virus NS2B/NS3 protease expressed in Escherichia coli BL21-Gold (DE3) using fluorogenic AMC-subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNonstructural protein 3(ZIKV)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50509461(CHEMBL4440832)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of Zika virus NS2B/NS3 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50509461(CHEMBL4440832)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of Dengue virus 2 NS2B-NS3 protease expressed in Escherichia coli BL21(DE3) using Boc-Gly-Arg-Arg-7-amino-4-methylcoumarin as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50509461(CHEMBL4440832)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of Dengue virus 2 GFP/DsRed fused NS2B-NS3 protease co-transfected in HEK293T cells by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50509461(CHEMBL4440832)
Affinity DataIC50: 990nMAssay Description:Inhibition of Dengue virus 3 NS2B-NS3 protease expressed in Escherichia coli BL21(DE3) using PhAc-Lys-Arg-Arg-AMC as substrate after 10 mins by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50509461(CHEMBL4440832)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of DENV2 NS2B-NS3 protease using Boc-Gly-Arg-Arg-7-amino-4-methylcoumarin as substrate incubated for 10 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Johannes Gutenberg University Mainz

Curated by ChEMBL
LigandPNGBDBM50509461(CHEMBL4440832)
Affinity DataIC50: 990nMAssay Description:Inhibition of DENV3 NS2B-NS3 protease using PhAc-Lys-Arg-Arg-AMC as substrate incubated for 10 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed