BDBM50509415 CHEMBL4462144::US11453697, Example 59

SMILES Nc1ncc2ncn([C@@H]3O[C@@H]4COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)O[C@H]4[C@H]3O)O[C@H]5n3cnc4c3nc(N)[nH]c4=O)c2n1

InChI Key InChIKey=XEFUAFFWLATQFJ-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50509415   

TargetStimulator of interferon genes protein(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences and Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509415(CHEMBL4462144 | US11453697, Example 59)
Affinity DataEC50:  40nMAssay Description:Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by brigh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences and Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509415(CHEMBL4462144 | US11453697, Example 59)
Affinity DataEC50:  5.39E+4nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells incubated for 7 hrs in absence of digitonin A by bright Glo-luciferase report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences and Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509415(CHEMBL4462144 | US11453697, Example 59)
Affinity DataEC50:  20nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences and Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509415(CHEMBL4462144 | US11453697, Example 59)
Affinity DataEC50:  40nMAssay Description:Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences and Gilead Sciences Research Centre At Iocb

Curated by ChEMBL
LigandPNGBDBM50509415(CHEMBL4462144 | US11453697, Example 59)
Affinity DataEC50:  700nMAssay Description:Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50509415(CHEMBL4462144 | US11453697, Example 59)
Affinity DataEC50:  11.8nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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