BDBM50509196 CHEMBL4461687

SMILES FC(F)(F)Oc1ccc(Cn2cc(CCC(=O)Nc3ccc(CCCCc4nnc(NC(=O)Cc5ccccn5)s4)nn3)nn2)cc1

InChI Key InChIKey=NRUFGXNJFOYGEN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50509196   

TargetGlutaminase kidney isoform, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50509196(CHEMBL4461687)
Affinity DataIC50: 390nMAssay Description:Inhibition of N-[2-[(3',6'-dihydroxy-1-oxo-spiro[isobenzofuran-3,9'-xanthene]-5-yl)carbamothioylamino]ethyl]-N'-[6-[4-[5-[[2-(2-pyridyl)acetyl]amino]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetGlutaminase kidney isoform, mitochondrial(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50509196(CHEMBL4461687)
Affinity DataIC50: 300nMAssay Description:Inhibition of human GLS1 expressed in Escherichia coli strain BL21 (DE3)pLysS pre-incubated for 10 mins before glutamine addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed