BDBM50509068 CHEMBL4515149

SMILES [3H]C([3H])([3H])N(C)[C@@H]1CCN(C1)c1ccnc(NCC(C)(C)C)n1

InChI Key InChIKey=QLLZULWFESFQOY-ZPHIIXCHSA-N

Data  11 KI  12 Kd  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50509068   

TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataEC50:  158nMAssay Description:Agonist activity at rat H4R expressed in in HEK293T cells by CRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Mouse)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataEC50:  7.94E+3nMAssay Description:Agonist activity at mouse H4R expressed in Sf9 cells by [35S]-GTPgammaS-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Mouse)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKd:  34nMAssay Description:Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataEC50:  5.01E+4nMAssay Description:Agonist activity at rat H4R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2 by [35S]-GTPgammaS-binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKd:  34nMAssay Description:Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKd:  22nMAssay Description:Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKd:  37nMAssay Description:Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKd:  34nMAssay Description:Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKd:  59nMAssay Description:Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells by kinetic binding studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Mouse)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKd:  15nMAssay Description:Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKd:  59nMAssay Description:Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Mouse)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataEC50:  200nMAssay Description:Agonist activity at mouse H4R expressed in HEK293T cells by CRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKd:  22nMAssay Description:Binding affinity to rat H4R expressed in HEK293T-SF-His6-CRE-Luc cells by saturation binding studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKd:  41nMAssay Description:Binding affinity to human H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Mouse)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKd:  17nMAssay Description:Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as equilibrium dissociation constant by saturation binding studyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Mouse)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKd:  34nMAssay Description:Binding affinity to mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cells assessed as kinetically derived dissociation constant by saturation binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKi:  355nMAssay Description:Displacement of [3H]-UR-DEBa176 from human H4R expressed in HEK293T-SF-His6-CRE-Luc cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Mouse)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKi:  490nMAssay Description:Displacement of [3H]-UR-DEBa176 from mouse H4R expressed in HEK293T-SF-His6-CRE-Luc cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKi:  501nMAssay Description:Displacement of [3H]histamine from human H3R expressed in human SK-N-MC-cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKi:  501nMAssay Description:Displacement of [3H]UR-PI294 from human H3R expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKi:  501nMAssay Description:Displacement of [3H]histamine from human H3R expressed in Sf9 cells co-expressing Galpha1 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKi:  501nMAssay Description:Displacement of [3H]histamine from human H3R expressed in Sf9 cells co-expressing RGS19 and Galpha1 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKi:  501nMAssay Description:Displacement of [3H]UR-PI294 from human H3R expressed in HEK293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKi:  501nMAssay Description:Displacement of [3H]UR-PI294 from human H3R expressed in Sf9 cells co-expressing RGS19 and Galphai2 and Gbeta1gamma2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKi:  501nMAssay Description:Displacement of [3H]histamine from human H3R expressed in HEK293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKi:  501nMAssay Description:Displacement of [3H]UR-PI294 from human H3R expressed in human SK-N-MC-cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Rat)
University of Regensburg

Curated by ChEMBL
LigandPNGBDBM50509068(CHEMBL4515149)
Affinity DataKi:  1.95E+3nMAssay Description:Displacement of [3H]-UR-DEBa176 from rat H4R expressed in HEK293T-SF-His6-CRE-Luc cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed