BDBM50508548 CHEMBL4560682

SMILES Cn1ccc2ccc(cc12)-c1cc(Nc2ccccc2S(C)(=O)=O)cc2nccnc12

InChI Key InChIKey=RGKAIQDQGWPKEQ-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50508548   

Target6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Human)
Selvita

Curated by ChEMBL

LigandBDBM50508548(CHEMBL4560682)Copy SMILESCopy InChI

Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PFKFB3 in human HCT116 cell lysates assessed as reduction in glycolytic-flux induced fructose-2,6-bisphosphate formation using fructose...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
Copy Entry DOIPubMed
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Target6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Human)
Selvita

Curated by ChEMBL

LigandBDBM50508548(CHEMBL4560682)Copy SMILESCopy InChI

Affinity DataIC50: 85nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL