BDBM50508541 CHEMBL4471750

SMILES CNC(=O)c1ccncc1Nc1cc(-c2ccc3ccn(C)c3c2)c2nccnc2c1

InChI Key InChIKey=MCBLLPDUYDRZBU-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50508541   

Target6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Human)
Selvita

Curated by ChEMBL

LigandBDBM50508541(CHEMBL4471750)Copy SMILESCopy InChI

Affinity DataIC50: 7.02E+3nMAssay Description:Inhibition of PFKFB3 in human HCT116 cell lysates assessed as reduction in glycolytic-flux induced fructose-2,6-bisphosphate formation using fructose...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

Target6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(Human)
Selvita

Curated by ChEMBL

LigandBDBM50508541(CHEMBL4471750)Copy SMILESCopy InChI

Affinity DataIC50: 83nMAssay Description:Inhibition of recombinant human His-tagged PFKFB3 expressed in Escherichia coli using fructose-6-phosphate as substrate measured after 2 hrs by ADP-G...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL