BDBM50508419 CHEMBL4471264

SMILES O=C1c2ccccc2C(=O)c2c(cccc12)-c1cnn(c1)C1CCNCC1

InChI Key InChIKey=RUCYSQLKCYBLDW-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50508419   

TargetUDP-glucuronosyltransferase 1A1(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50508419(CHEMBL4471264)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of UGT1A1 in human liver microsomes assessed as reduction in SN-38 glucuronidation by tandem mass spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetUDP-glucuronosyltransferase 2B7(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50508419(CHEMBL4471264)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of UGT2B7 in human liver microsomes assessed as reduction in naloxone 3-glucuronidation by tandem mass spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetUDP-glucuronosyltransferase 1A9(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50508419(CHEMBL4471264)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of UGT1A9 in human liver microsomes assessed as reduction in mycophenolic acid glucuronidation by tandem mass spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetUDP-glucuronosyltransferase 1A4(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50508419(CHEMBL4471264)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of UGT1A4 in human liver microsomes assessed as reduction in trifluoperazine N-glucuronidation by tandem mass spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50508419(CHEMBL4471264)
Affinity DataIC50: 4.24E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as reduction in omeprazole hydroxylation by tandem mass spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50508419(CHEMBL4471264)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as reduction in tolbutamide 4-hydroxylation by tandem mass spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50508419(CHEMBL4471264)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as reduction in dextromethorphan O-demethylation by tandem mass spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50508419(CHEMBL4471264)
Affinity DataIC50: 84nMAssay Description:Inhibition of PDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A43/3A5/3A7(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50508419(CHEMBL4471264)
Affinity DataIC50: 3.66E+4nMAssay Description:Inhibition of CYP3A in human liver microsomes assessed as reduction in midazolam 1'-hydroxylation by tandem mass spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50508419(CHEMBL4471264)
Affinity DataIC50: 1.63E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes assessed as reduction in phenacetin-O-deethylation by tandem mass spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed