BDBM505080 (6-Benzo[1,3]dioxol-5-yl-2-fluoro-3-methoxy-phenyl)-[(S)-2-(5-chloro-4-methyl-1H-benzoimidazol-2-yl)-2-methyl-pyrrolidin-1-yl]-methanone::US11040966, Example 5.304

SMILES COc1ccc(-c2ccc3OCOc3c2)c(C(=O)N2CCC[C@@]2(C)c2nc3c(C)c(Cl)ccc3[nH]2)c1F

InChI Key InChIKey=RIEPGLIGKPPHQM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 505080   

TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM505080((6-Benzo[1,3]dioxol-5-yl-2-fluoro-3-methoxy-phenyl...)
Affinity DataIC50: 19nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM505080((6-Benzo[1,3]dioxol-5-yl-2-fluoro-3-methoxy-phenyl...)
Affinity DataIC50: 86nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
Go to US Patent