BDBM50507701 CHEMBL4464975::US11535598, Compound 9

SMILES ONC(=O)c1ccc(Cn2c3ccc(Cl)cc3c(=O)n(CCc3ccccc3)c2=O)cc1

InChI Key InChIKey=GBGUZOXTJDMNRI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50507701   

TargetHistone deacetylase 6(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507701(CHEMBL4464975 | US11535598, Compound 9)
Affinity DataIC50: 35nMAssay Description:Inhibition of human full-length recombinant HDAC6 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKKAc as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507701(CHEMBL4464975 | US11535598, Compound 9)
Affinity DataIC50: 1.89E+4nMAssay Description:Inhibition of human full-length recombinant HDAC1 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKKAc as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507701(CHEMBL4464975 | US11535598, Compound 9)
Affinity DataIC50: 1.89E+4nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507701(CHEMBL4464975 | US11535598, Compound 9)
Affinity DataIC50: 35nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507701(CHEMBL4464975 | US11535598, Compound 9)
Affinity DataIC50: 1.89E+4nMAssay Description:Inhibition of human HDAC1 expressed in baculovirus expression system in Sf9 cells using RHKKAc (379 to 382 residues) fluorogenic peptide as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507701(CHEMBL4464975 | US11535598, Compound 9)
Affinity DataIC50: 35nMAssay Description:Inhibition of human HDAC6 expressed in baculovirus expression system in Sf9 cells using RHKKAc (379 to 382 residues) fluorogenic peptide as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed