BDBM50507691 CHEMBL4513424::US11535598, Compound 13

SMILES ONC(=O)c1ccc(Cn2c3cc(ccc3c(=O)n(CCc3ccccc3)c2=O)C(F)(F)F)cc1

InChI Key InChIKey=LDANZSVZHVZFQZ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50507691   

TargetHistone deacetylase 1(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507691(CHEMBL4513424 | US11535598, Compound 13)
Affinity DataIC50: 8.02E+3nMAssay Description:Inhibition of human full-length recombinant HDAC1 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKKAc as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507691(CHEMBL4513424 | US11535598, Compound 13)
Affinity DataIC50: 7.39E+3nMAssay Description:Inhibition of human full-length recombinant HDAC11 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKKAc as substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507691(CHEMBL4513424 | US11535598, Compound 13)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of human full-length recombinant HDAC8 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKAcKAc as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507691(CHEMBL4513424 | US11535598, Compound 13)
Affinity DataIC50: 636nMAssay Description:Inhibition of human full-length recombinant HDAC6 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKKAc as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507691(CHEMBL4513424 | US11535598, Compound 13)
Affinity DataIC50: 8.02E+3nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507691(CHEMBL4513424 | US11535598, Compound 13)
Affinity DataIC50: 1.44E+3nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507691(CHEMBL4513424 | US11535598, Compound 13)
Affinity DataIC50: 635nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 11(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507691(CHEMBL4513424 | US11535598, Compound 13)
Affinity DataIC50: 7.39E+3nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507691(CHEMBL4513424 | US11535598, Compound 13)
Affinity DataIC50: 8.02E+3nMAssay Description:Inhibition of human HDAC1 expressed in baculovirus expression system in Sf9 cells using RHKKAc (379 to 382 residues) fluorogenic peptide as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507691(CHEMBL4513424 | US11535598, Compound 13)
Affinity DataIC50: 636nMAssay Description:Inhibition of human HDAC6 expressed in baculovirus expression system in Sf9 cells using RHKKAc (379 to 382 residues) fluorogenic peptide as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Annji Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50507691(CHEMBL4513424 | US11535598, Compound 13)
Affinity DataIC50: 1.44E+3nMAssay Description:Inhibition of human HDAC8 expressed in baculovirus expression system in Sf9 cells using RHKAcKAc (379 to 382 residues) fluorogenic peptide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed