BDBM50507434 CHEMBL4546784

SMILES CNC(=O)c1c(oc2ccc(cc12)-c1cccc(c1)C(=O)NC1(CC1)c1ccccn1)-c1ccc(F)cc1

InChI Key InChIKey=JZKYEGPUISOCLD-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50507434   

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50507434(CHEMBL4546784)
Affinity DataEC50:  36nMAssay Description:Inhibition of HCV genotype 1a NS5B RNA dependent RNA polymerase infected in human HuH7 replicon cells after 3 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50507434(CHEMBL4546784)
Affinity DataEC50:  3.80nMAssay Description:Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase infected in human HuH7 replicon cells after 3 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50507434(CHEMBL4546784)
Affinity DataEC50:  75nMAssay Description:Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase C316N mutant infected in human HuH7 replicon cells after 3 days by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50507434(CHEMBL4546784)
Affinity DataEC50:  515nMAssay Description:Inhibition of HCV genotype 2a JFH1 NS5B RNA dependent RNA polymerase infected in human HuH7 replicon cells after 3 days by luciferase reporter gene a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed