BDBM50507405 CHEMBL4577928

SMILES OC(=O)CNC(=O)c1c(O)c2COCc2n(Cc2ccc(cc2)C(F)(F)F)c1=O

InChI Key InChIKey=YAXLMMDYZWFFAQ-UHFFFAOYSA-N

Data  8 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50507405   

LigandPNGBDBM50507405(CHEMBL4577928)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50507405(CHEMBL4577928)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of CysLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507405(CHEMBL4577928)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50507405(CHEMBL4577928)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProlyl hydroxylase EGLN3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50507405(CHEMBL4577928)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of recombinant human HIF-PHD3 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL and 2-oxoglutarate as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEgl nine homolog 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50507405(CHEMBL4577928)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of recombinant human HIF-PHD2 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL and 2-oxoglutarate as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
Target1,3-beta-glucan synthase component GSC2(Baker's yeast)
Merck

Curated by ChEMBL
LigandPNGBDBM50507405(CHEMBL4577928)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of iKr (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507405(CHEMBL4577928)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of human PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProlyl hydroxylase EGLN2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50507405(CHEMBL4577928)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant human HIF-PHD1 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL and 2-oxoglutarate as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed