BDBM50507364 CHEMBL4590548

SMILES NC(=O)c1cc(cc2c(c[nH]c12)C1CCS(=O)(=O)CC1)-c1ccccc1

InChI Key InChIKey=XNXQMKGGFGDFEC-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50507364   

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50507364(CHEMBL4590548)Copy SMILESCopy InChI

Affinity DataIC50: 80nMAssay Description:Inhibition of IKKbeta in human CD14-positive monocytes assessed as reduction in LPS-stimulated TNFalpha secretion preincubated for 30 mins followed b...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50507364(CHEMBL4590548)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human C-terminal GST-tagged IKKbeta (1 to 737 residues) expressed in baculovirus expression system using GST-IkBalpha subst...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL