BDBM50507355 CHEMBL4565091

SMILES CC1(C)C[C@@H](CCS1(=O)=O)c1c[nH]c2c(cc(cc12)-c1ccc(F)cc1)C(N)=O

InChI Key InChIKey=YGYGASJNJTYNOL-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50507355   

TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50507355(CHEMBL4565091)Copy SMILESCopy InChI

Affinity DataIC50: 7.90nMAssay Description:Inhibition of recombinant human C-terminal GST-tagged IKKbeta (1 to 737 residues) expressed in baculovirus expression system using GST-IkBalpha subst...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
Copy Entry DOIPubMed
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TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Glaxosmithkline

Curated by ChEMBL

LigandBDBM50507355(CHEMBL4565091)Copy SMILESCopy InChI

Affinity DataIC50: 130nMAssay Description:Inhibition of IKKbeta in human CD14-positive monocytes assessed as reduction in LPS-stimulated TNFalpha secretion preincubated for 30 mins followed b...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL