BDBM50507079 CHEMBL2346855

SMILES CCCc1ccc(OCC(=O)N(Cc2nc(no2)-c2cccnc2)C(C)C)cc1

InChI Key InChIKey=ZVVXAODXPVWGMF-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50507079   

TargetProteasome subunit beta type-2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50507079(CHEMBL2346855)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human trypsin-like activity of 20S constitutive proteasome using Z-VLR-AMC as substrate preincubated for 15 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50507079(CHEMBL2346855)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human caspase-like activity of 20S constitutive proteasome preincubated for 15 mins followed by substrate addition by fluorescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50507079(CHEMBL2346855)
Affinity DataIC50: 92nMAssay Description:Inhibition of human chymotrypsin-like activity of 20S constitutive proteasome using Suc-LLVY-AMC as substrate preincubated for 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50507079(CHEMBL2346855)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 20S immunoproteasome LMP7 (unknown origin) using Ac-ANW-AMC as substrate preincubated for 15 mins followed by substrate addition by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50507079(CHEMBL2346855)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of trypsin-like activity of human 20S proteasome beta 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details
PubMed
TargetProteasome subunit beta type-1(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50507079(CHEMBL2346855)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of caspase-like activity of human 20S proteasome beta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50507079(CHEMBL2346855)
Affinity DataIC50: 27nMAssay Description:Inhibition of 20s constitutive proteasome beta-5c (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50507079(CHEMBL2346855)
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of 20s immunoproteasome beta-5i subunit (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50507079(CHEMBL2346855)
Affinity DataIC50: 5nMAssay Description:Inhibition of human 20s constitutive proteasome beta-5cMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50507079(CHEMBL2346855)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 20s immunoproteasome beta-5i subunitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed