BDBM50507005 CHEMBL4475108

SMILES COc1ccc(Nc2nc(nc3ccccc23)-c2ccc[nH]2)cc1OC

InChI Key InChIKey=NYRQNTJRMWEOOQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50507005   

TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50507005(CHEMBL4475108)
Affinity DataIC50: 1.81E+3nMAssay Description:Inhibition of ABCB1 in human A2780/ADR cells assessed as calcein-AM accumulation preincubated for 30 mins followed by calcein-AM addition measured ov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50507005(CHEMBL4475108)
Affinity DataIC50: 1.73E+4nMAssay Description:Inhibition of ABCC1 in human H69AR cells assessed as calcein-AM accumulation preincubated for 30 mins followed by calcein-AM addition measured over 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50507005(CHEMBL4475108)
Affinity DataIC50: 652nMAssay Description:Inhibition of GFP-fused human ABCG2 expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins followed by Hoechst 3334...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed