BDBM50507004 CHEMBL4448170

SMILES COc1ccc(Nc2nc(nc3ccccc23)-c2ccc[nH]2)cc1

InChI Key InChIKey=YJHNRAMBIDBLJQ-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50507004   

TargetATP-dependent translocase ABCB1(Human)
University of Bonn

Curated by ChEMBL

LigandBDBM50507004(CHEMBL4448170)Copy SMILESCopy InChI

Affinity DataIC50: 8.03E+3nMAssay Description:Inhibition of ABCB1 in human A2780/ADR cells assessed as calcein-AM accumulation preincubated for 30 mins followed by calcein-AM addition measured ov...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
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TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Bonn

Curated by ChEMBL

LigandBDBM50507004(CHEMBL4448170)Copy SMILESCopy InChI

Affinity DataIC50: 2.57E+3nMAssay Description:Inhibition of GFP-fused human ABCG2 expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins followed by Hoechst 3334...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL