BDBM50506873 CHEMBL4435412

SMILES [H][C@@]12CC(C)(C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)Cc4nccnc4[C@@](C)(CO)[C@]3([H])CC[C@@]12C)C(=O)OCCCN(C)C

InChI Key InChIKey=YQHYRNLWHCPXOV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50506873   

TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50506873(CHEMBL4435412)
Affinity DataIC50: 1.59E+3nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50506873(CHEMBL4435412)
Affinity DataIC50: 1.27E+4nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50506873(CHEMBL4435412)
Affinity DataIC50: 4.98E+4nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50506873(CHEMBL4435412)
Affinity DataIC50: 1.72E+4nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50506873(CHEMBL4435412)
Affinity DataIC50: 3.50E+4nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50506873(CHEMBL4435412)
Affinity DataIC50: 2.12E+4nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed