BDBM50506814 CHEMBL4513619

SMILES Brc1cccc(NC(=O)CCN2CCc3ccccc3C2)c1C#N

InChI Key InChIKey=RFPVZTZIBYRPGW-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50506814   

LigandPNGBDBM50506814(CHEMBL4513619)
Affinity DataKd:  1.08E+4nMAssay Description:Binding affinity to PRMT5 (unknown origin)/MEP50 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
University of Jinan

Curated by ChEMBL
LigandPNGBDBM50506814(CHEMBL4513619)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of PRMT4 (unknown origin) pretreated for 15 mins followed by substrate and [3H]-SAM addition measured after 60 mins by scintillation proxi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandPNGBDBM50506814(CHEMBL4513619)
Affinity DataIC50: 2.71E+3nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
University of Jinan

Curated by ChEMBL
LigandPNGBDBM50506814(CHEMBL4513619)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of PRMT1 (unknown origin) pretreated for 15 mins followed by substrate and [3H]-SAM addition measured after 60 mins by scintillation proxi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed