BDBM50506790 CHEMBL4574840

SMILES COc1ccc2nc(nc(NC3CCN(Cc4ccccc4)CC3)c2c1)N1CCN(CC1)c1ccccc1

InChI Key InChIKey=ZRXRPMAQFMQWBA-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50506790   

TargetDNA (cytosine-5)-methyltransferase 3A(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50506790(CHEMBL4574840)
Affinity DataEC50:  5.40E+3nMAssay Description:Inhibition of recombinant human DNMT3a C-terminal catalytic domain (623 to 908 residues) using 5'-biotinylated/3'-FAM-oligonucleotide as substrate me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50506790(CHEMBL4574840)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of recombinant human DNMT1 using biotinylated DNA duplex as substrate measured after 2 hrs in presence of Adomet/[methyl-3H]Adomet by topc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed