BDBM50506715 CHEMBL4449918

SMILES Cc1cc2nc3\C(=N/O)c4ccccc4-c3nc2cc1C

InChI Key InChIKey=NERJSNYOGGKVRR-UHFFFAOYSA-N

Data  2 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50506715   

TargetMitogen-activated protein kinase 9(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506715(CHEMBL4449918)
Affinity DataKd:  2.50E+3nMAssay Description:Binding affinity to human full-length JNK2 (M1 to Q382 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506715(CHEMBL4449918)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to human partial length JNK3 (V28 to Q422 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506715(CHEMBL4449918)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506715(CHEMBL4449918)
Affinity DataIC50: 600nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506715(CHEMBL4449918)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to human full-length JNK1 (M1 to Q384 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed