BDBM50506712 CHEMBL4583031

SMILES O\N=C1\c2ccccc2-c2nc3cc(Cl)ccc3nc12

InChI Key InChIKey=UUCUQQSPAIGSDY-UHFFFAOYSA-N

Data  2 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50506712   

TargetMitogen-activated protein kinase 8(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506712(CHEMBL4583031)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to human full-length JNK1 (M1 to Q384 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506712(CHEMBL4583031)
Affinity DataKd:  2.15E+4nMAssay Description:Binding affinity to human full-length JNK2 (M1 to Q382 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506712(CHEMBL4583031)
Affinity DataKd:  710nMAssay Description:Binding affinity to human partial length JNK3 (V28 to Q422 residues) expressed in HEK293 cells measured after 1 hr by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506712(CHEMBL4583031)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation preincubated for 30 mins followed by LPS-stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10/8/9(Human)
Montana State University

Curated by ChEMBL
LigandPNGBDBM50506712(CHEMBL4583031)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production preincubated for 30 mins followed by LPS-stimulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed