BDBM50506615 CHEMBL4452474

SMILES COCc1ccc(cc1)-c1ccc(cc1)N(C[C@@H](N)[C@@H](C)OC)C(=O)[C@@H]1C[C@H]1c1ccccn1

InChI Key InChIKey=XCHHIKJEGXHKLQ-UHFFFAOYSA-N

Data  2 KI  1 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50506615   

TargetProbable G-protein coupled receptor 88(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50506615(CHEMBL4452474)
Affinity DataEC50:  100nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 88(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50506615(CHEMBL4452474)
Affinity DataEC50:  535nMAssay Description:Agonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50506615(CHEMBL4452474)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as reduction in SERT-mediated substrate uptake after 30 mins by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 88(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50506615(CHEMBL4452474)
Affinity DataEC50:  100nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 88(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50506615(CHEMBL4452474)
Affinity DataEC50:  100nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetProbable G-protein coupled receptor 88(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50506615(CHEMBL4452474)
Affinity DataEC50:  100nMAssay Description:Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50506615(CHEMBL4452474)
Affinity DataKi:  750nMAssay Description:Displacement of [3H]-Paroxetine from recombinant human full length SERT after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50506615(CHEMBL4452474)
Affinity DataKi:  2.29E+3nMAssay Description:Binding affinity to human full length KOR after 60 mins by radioligand-based scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed