BDBM50506263 CHEMBL4465054::US11401295, Compound 2',3'-cGAMP

SMILES [H][C@]12COP(O)(=O)O[C@@]3([H])[C@@H](O)[C@@H](O[C@]3([H])COP(O)(=O)O[C@@]([H])([C@@H](O1)n1cnc3c1nc(N)[nH]c3=O)[C@@H]2O)n1cnc2c(N)ncnc12

InChI Key InChIKey=XRILCFTWUCUKJR-UHFFFAOYSA-N

Data  3 IC50  5 Kd  28 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 53 hits for monomerid = 50506263   

LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataKd: <0.0100nMAssay Description:Binding affinity to wild type mouse STING assessed as dissociation constant by Surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataIC50: 0.630nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataIC50: 1.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataIC50: 1.80nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataKd:  1.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataKd:  3.79nMAssay Description:Binding affinity to wild type human STING (139 to 379 residues) by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataKd:  3.80nMAssay Description:Binding affinity to wild-type STING (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataIC50: 5.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of anti 6His antibody-labeled terbium cryptate binding to human wild-type full-length 6His-tagged d2-labeled STING measured after 4 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  5.80nMAssay Description:Binding affinity to 6His-tagged human STING measured after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2022
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataKd:  6.20nMAssay Description:Binding affinity to wild type human STING assessed as dissociation constant by Surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataKd:  13nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  20nMAssay Description:Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  20nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  20nMAssay Description:Agonist activity at STING R71H/G230A/R293Q mutant (unknown origin) expressed in digitonin -permeabilized HEK293T cells preincubated for 30 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  20nMAssay Description:Agonist activity at STING R232 mutant (unknown origin) expressed in digitonin -permeabilized HEK293T cells preincubated for 30 mins followed by washo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataKd:  24nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  28nMAssay Description:Agonist activity at STING in PMA-treated human THP-1 reporter cells incubated for 30 mins in presence of digitonin by QUANTI-Luc assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  40nMAssay Description:Agonist activity at STING G230A/R293Q mutant (unknown origin) expressed in digitonin -permeabilized HEK293T cells preincubated for 30 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  40nMAssay Description:Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by brigh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  50nMAssay Description:Binding affinity to human STING incubated for 60 mins measured by competitive TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  50nMAssay Description:Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  50nMAssay Description:Agonist activity at STING R293Q mutant (unknown origin) expressed in digitonin -permeabilized HEK293T cells preincubated for 30 mins followed by wash...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  131nMAssay Description:Agonist activity at STING in human THP-1 reporter cells incubated for 4 hrs in presence of lipofectamine 2000 by QUANTI-Luc assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataKd:  3.79E+3nMAssay Description:Agonist activity at wild type human STING C-terminal domain (139 to 379 residues) assessed as dissociation constant by isothermal titration calorimet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataIC50: 4.19E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataKd:  6.43E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetStimulator of interferon genes protein [140-379](Mountain lion)
Shanghai Jemincare Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataIC50: 6.66E+3nMAssay Description:Fluorescence polarization assay (FP assay) was used to detect the affinity of compounds for human STING proteins. There were a certain amount of fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  7.20E+3nMAssay Description:Activation of STING in human THP-1-Dual cells assessed as induction of type I IFNs by measuring stimulation of IRF pathway incubated for 48 hrs by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  1.06E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  1.14E+4nMAssay Description:Agonist activity at STING in human THP1-Dual cells incubated for 20 hrs by Quanti-luc reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  1.28E+4nMAssay Description:Activation of STING signalling pathway in human PBMC cells assessed as increase in CXCL10 level incubated for 4 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  1.37E+4nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells incubated for 7 hrs in absence of digitonin A by bright Glo-luciferase report...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  1.38E+4nMAssay Description:Agonist activity at STING in mouse RAW-Lucia ISG cells by luciferase gene reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  1.40E+4nMAssay Description:Activation of STING signalling pathway in human PBMC cells assessed as increase in IFN-beta level incubated for 4 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  1.55E+4nMAssay Description:Agonist activity at STING in wildtype human THP1-Dual cells assessed as IRF activation incubated for 24 hrs by QUANTI-Luc reagent based luminescence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataIC50: 1.83E+4nMAssay Description:Displacement of 2'-Fluo-AHC-c-di-GMP from wildtype human STING expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polariza...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  1.88E+4nMAssay Description:Activation of STING in mouse RAW-Lucia ISG cells assessed as induction of type I IFNs stimulation by measuring induction of IRF pathway incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  1.90E+4nMAssay Description:Activation of STING signalling pathway in human THP1-Dual cells assessed as increase in IRF-luciferase activation incubated for 24 hrs by QUANTI-luc ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  1.96E+4nMAssay Description:Activation of STING in human blood assessed as induction of type I IFNs incubated for 18 to 20 hrs by QUANTI-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  1.96E+4nMAssay Description:Agonist activity at STING (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  1.98E+4nMAssay Description:Agonist activity at STING in human THP1-Dual KI-hSTING-R232 cells assessed as IRF activation incubated for 24 hrs by QUANTI-Luc reagent based lumines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  2.50E+4nMAssay Description:Activation of STING signalling pathway in human PBMC cells assessed as increase in IL-6 level incubated for 4 hrs by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  2.70E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  3.01E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  3.69E+4nMAssay Description:Agonist activity at wild type STING (unknown origin) expressed in HEK293T cells measured after 7 hrs by Bright-glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  3.86E+4nMAssay Description:Agonist activity at STING in human THP1 cells assessed as stimulation of IRF3 pathway measured after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  3.91E+4nMAssay Description:Activation of STING in human THP-1-Dual cells assessed as induction of type I IFNs by measuring stimulation of NF-kappaB pathway incubated for 48 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  4.38E+4nMAssay Description:Activation of STING signalling pathway in human THP1-Dual cells assessed as increase in NF-kappaB-SEAP activation incubated for 24 hrs by QUANTI-Blue...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Beijing Institute of Pharmacology and Toxicology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50506263BDBM50506263(CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP)
Affinity DataEC50:  4.86E+4nMAssay Description:Agonist activity at STING in human THP-1 reporter cells incubated for 24 hrs by QUANTI-Luc assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
Displayed 1 to 50 (of 53 total ) | Next | Last >>