BDBM50506257 CHEMBL4456973

SMILES CCn1nc(C)cc1C(=O)Nc1nc2cc(cc(OC)c2n1CCCNC(=O)OC(C)(C)C)C(N)=O

InChI Key InChIKey=MPOVOZSRJRSWHB-UHFFFAOYSA-N

Data  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50506257   

TargetStimulator of interferon genes protein(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50506257(CHEMBL4456973)
Affinity DataEC50:  1.79E+3nMAssay Description:Agonist activity at STING in human PBMC cells assessed as increase in IFNbeta release measured after 4 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50506257(CHEMBL4456973)
Affinity DataEC50:  1.24E+3nMAssay Description:Agonist activity at STING in human THP1 cells assessed as stimulation of IRF3 pathway measured after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50506257(CHEMBL4456973)
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of anti 6His antibody-labeled terbium cryptate binding to human wild-type full-length 6His-tagged d2-labeled STING measured after 4 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetInterferon regulatory factor 3(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50506257(CHEMBL4456973)
Affinity DataEC50: >1.00E+5nMAssay Description:Induction of IRF3 pathway in STING knockout human THP1 cells measured after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed