BDBM50506159 CHEMBL1532400

SMILES CC(C)c1cc(c(c(c1)Br)NC(=O)Nc2cccnc2)Br

InChI Key InChIKey=JFNKIJKRXKPQCC-UHFFFAOYSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50506159   

TargetP2X purinoceptor 4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50506159(CHEMBL1532400)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in human HEK293 cells at -60 mv holding potential by Whole cell patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50506159(CHEMBL1532400)
Affinity DataIC50: 780nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in human HEK293 cells assessed as inhibition of ATP-induced calcium influx by Fluo2-AM staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50506159(CHEMBL1532400)
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at human P2X4R transfected in HEK293 cells assessed as inhibition of ATP-mediated calcium influx measured after 10 mins by YOPRO-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50506159(CHEMBL1532400)
Affinity DataIC50: 540nMAssay Description:Antagonist activity at human P2X4R transfected in HEK293 cells assessed as inhibition of ATP-evoked current by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50506159(CHEMBL1532400)
Affinity DataIC50: 1.60E+3nMAssay Description:Antagonist activity at human P2X4R transfected in 1321N1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50506159(CHEMBL1532400)
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at human P2X4R transfected in HEK293 cells assessed as inhibition of ATP-mediated calcium influx measured after 10 mins by YOPRO-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50506159(CHEMBL1532400)
Affinity DataIC50: 1.60E+3nMAssay Description:Antagonist activity at human P2X4R transfected in 1321N1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50506159(CHEMBL1532400)
Affinity DataIC50: 550nMAssay Description:Antagonist activity at human P2X4R transfected in 1321N1 cells assessed as inhibition of ATP-mediated calcium influx measured after 10 mins by Fura-2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50506159(CHEMBL1532400)
Affinity DataIC50: 550nMAssay Description:Antagonist activity at human P2X4R transfected in 1321N1 cells assessed as inhibition of ATP-mediated calcium influx measured after 10 mins by Fura-2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50506159(CHEMBL1532400)
Affinity DataIC50: 540nMAssay Description:Antagonist activity at human P2X4R transfected in HEK293 cells assessed as inhibition of ATP-evoked current by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50506159(CHEMBL1532400)
Affinity DataIC50: 1.95E+3nMAssay Description:Antagonist activity at P2X4R (unknown origin) expressed in 1321N1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetP2X purinoceptor 4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50506159(CHEMBL1532400)
Affinity DataIC50: 904nMAssay Description:Antagonist activity against human P2X4R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed