BDBM50505851 CHEMBL4583133

SMILES COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NO

InChI Key InChIKey=KQRQPMUPYDOTCA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50505851   

TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50505851(CHEMBL4583133)
Affinity DataIC50: 8.45E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in mouse J774A.1 cells assessed as reduction in IL-1beta level preincubated for 2 hrs followed by LPS-sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50505851(CHEMBL4583133)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of NLRP3 in mouse J774A.1 cells infected with FLA-ST assessed as inhibition of LPS- induced IL-1beta production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50505851(CHEMBL4583133)
Affinity DataIC50: 8.45E+3nMAssay Description:Inhibition of NLRP3 (unknown origin) assessed as reduction of IL-1beta productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed