BDBM50505763 CHEMBL4466288

SMILES Fc1ccc(cc1)-c1ccc([C@H](Cn2ccnc2)NC(=O)c2ccc(cc2)-c2nnc(o2)-c2cc(ccc2F)-c2ccccn2)c(Cl)c1

InChI Key InChIKey=FXWUIEFJAFDYSH-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50505763   

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50505763(CHEMBL4466288)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant full length human CYP51 expressed in Escherichia coli incubated for 1 min using [3H] lanosterol as substrate by HPLC analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50505763(CHEMBL4466288)
Affinity DataKd:  2.50E+3nMAssay Description:Binding affinity to recombinant full length human CYP51 expressed in Escherichia coli incubated for 30 sec using [3H] labelled substrate by HPLC anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50505763(CHEMBL4466288)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of recombinant full length human CYP51 expressed in Escherichia coli incubated for 1 hr using [3H] lanosterol as substrate by HPLC analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed