BDBM50505629 CHEMBL4436772

SMILES Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCCCC2)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)Nc1ccc(cc1)C(=O)NCCCCCc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O

InChI Key InChIKey=RRSNDVCODIMOFX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50505629   

TargetProtein cereblon(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50505629(CHEMBL4436772)
Affinity DataIC50: 5.5nMAssay Description:Binding affinity to cereblon in human RV4:11 cells expressing wild type p53 assessed as cell growth inhibition measured after 4 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProtein cereblon(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50505629(CHEMBL4436772)
Affinity DataIC50: 10nMAssay Description:Binding affinity to cereblon in human RV4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as cell growth inhibition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProtein cereblon(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50505629(CHEMBL4436772)
Affinity DataIC50: 10nMAssay Description:Binding affinity to cereblon in human MDA-MB-231 cells assessed as cell growth inhibition measured after 4 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProtein cereblon(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50505629(CHEMBL4436772)
Affinity DataIC50: 10nMAssay Description:Binding affinity to cereblon in human MDA-MB-468 cells assessed as cell growth inhibition measured after 4 daysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed