BDBM50505362 CHEMBL4470807

SMILES Brc1ccc(Sc2ccc3C(C#N)=C(C#N)C(=O)c4cccc2c34)cc1

InChI Key InChIKey=IFUUTGNBTBDNHL-UHFFFAOYSA-N

Data  3 KI  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50505362   

TargetApoptosis regulator Bcl-2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50505362(CHEMBL4470807)
Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of biotinylated Bim peptide (81 to 106 residues) binding to His-tagged human Bcl-2 expressed in Escherichia coli BL21 (DE3) cells preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50505362(CHEMBL4470807)
Affinity DataIC50: 2.03E+3nMAssay Description:Inhibition of biotinylated Bim peptide (81 to 106 residues) binding to His-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) cells preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50505362(CHEMBL4470807)
Affinity DataIC50: 700nMAssay Description:Inhibition of FAM-Bim peptide binding to human Bcl-2 (2 to 206) measured after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50505362(CHEMBL4470807)
Affinity DataKd:  430nMAssay Description:Binding affinity to wildtype Mcl-1 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM50505362(CHEMBL4470807)
Affinity DataKi:  490nMAssay Description:Inhibition of FAM-Bim peptide binding to MCl1 (unknown origin) measured after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50505362(CHEMBL4470807)
Affinity DataKi:  750nMAssay Description:Inhibition of FAM-Bim peptide binding to Bcl-xl (unknown origin) measured after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50505362(CHEMBL4470807)
Affinity DataKi:  850nMAssay Description:Inhibition of FAM-Bim peptide binding to human full-length N-terminal His6-tagged Bcl2 (2 to 206 residues) expressed in Escherichia coli S12 extract ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed