BDBM50505326 CHEMBL4524437

SMILES COc1cccc2c1nc([nH]c2=O)-c1ccc(cc1)C(C)(C)O

InChI Key InChIKey=NGWLKFVMSQZGRO-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50505326   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50505326(CHEMBL4524437)
Affinity DataIC50: 43nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50505326(CHEMBL4524437)
Affinity DataIC50: 630nMAssay Description:Inhibition of recombinant human full-length Myc/His-tagged Parp-1 expressed in baculovirus infected Sf21 insect cells assessed as reduction in auto-P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50505326(CHEMBL4524437)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of tankyrase 1/2 in human DLD1 cells assessed as increase in axin2 accumulation incubated for 24 hrs by luminex based bead assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50505326(CHEMBL4524437)
Affinity DataIC50: 35nMAssay Description:Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed