BDBM50504093 CHEMBL4516321

SMILES CC(=O)NCCNCc1cc(C)c(OCc2cccc(c2C)-c2ccccc2)cc1OCc1cncc(c1)C#N

InChI Key InChIKey=RGUPKQRLKVPKIF-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50504093   

TargetProgrammed cell death 1 ligand/protein 1(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50504093(CHEMBL4516321)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human Fc-tagged PD1 N-terminal domain (Leu25 to Gln167 residues) expressed in HEK293 cells/human His-tagged PDL1 (Phe19 to Arg238 resid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50504093(CHEMBL4516321)
Affinity DataEC50:  219nMAssay Description:Inhibition of PD1/PDL1 interaction in human Jurkat cells co-cultured with human U2OS cells expressing PDL1 assessed as reduction in SHP1 recruitment ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50504093(CHEMBL4516321)
Affinity DataEC50:  3.00E+3nMAssay Description:Inhibition of human PD1 stably expressed in human Jurkat T cells co-expressing NFAT-induced luciferase/human PDL1 stably expressed in CHOK1 cells co-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed